Non-invasive Neuromodulation of Spinal Cord Restores Lower Urinary Tract Function After Paralysis.

ABSTRACT: It is commonly assumed that restoration of locomotion is the ultimate goal after spinal cord injury (SCI). However, lower urinary tract (LUT) dysfunction is universal among SCI patients and significantly impacts their health and quality of life. Micturition is a neurologically complex behavior that depends on intact sensory and motor innervation. SCI disrupts both motor and sensory function and leads to marked abnormalities in urine storage and emptying. Current therapies for LUT dysfunction after SCI focus on preventing complications and managing symptoms rather than restoring function. In this study, we demonstrate that Transcutaneous Electrical Spinal Stimulation for LUT functional Augmentation (TESSLA), a non-invasive neuromodulatory technique, can reengage the spinal circuits' active

SUBMITTER: Gad PN 

PROVIDER: S-EPMC6034097 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature