Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development.

ABSTRACT: Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at

SUBMITTER: Koszinowski S 

PROVIDER: S-EPMC6034111 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature