Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction.

ABSTRACT:

Background

Cardiac reserve is depressed in patients with heart failure and preserved ejection fraction (HFpEF). The mechanisms causing this are poorly understood.

Objectives

The authors hypothesized that myocardial injury might contribute to the hemodynamic derangements and cardiac reserve limitations that are present in HFpEF. Markers of cardiomyocyte injury, central hemodynamics, ventricular function, and determinants of cardiac oxygen supply-demand balance were measured.

Methods

Subjects with HFpEF (n = 38) and control subjects without heart failure (n = 20) underwent cardiac catheterization, echocardiography, and expired gas analysis at rest and during exercise. Central venous blood was sampled to measure plasma high-sensitivity troponin T levels as an index of ca

SUBMITTER: Obokata M 

PROVIDER: S-EPMC6034112 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature