Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

ABSTRACT: Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

SUBMITTER: Clulow JA 

PROVIDER: S-EPMC6034444 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature