Maintenance antipsychotic treatment versus discontinuation strategies following remission from first episode psychosis: systematic review.

ABSTRACT:

Background

Understanding the relative risks of maintenance treatment versus discontinuation of antipsychotics following remission in first episode psychosis (FEP) is an important area of practice.

Method

A systematic review and meta-analysis. Prospective experimental studies including a parallel control group were identified to compare maintenance antipsychotic treatment with total discontinuation or medication discontinuation strategies following remission in FEP.

Results

Seven studies were included. Relapse rates were higher in the discontinuation group (53%; 95% CIs: 39%, 68%; N = 290) compared with maintenance treatment group (19%; 95% CIs: 0.05%, 37%; N = 230). In subgroup analyses, risk difference of relapse was lower in studies with a longer follo

SUBMITTER: Thompson A 

PROVIDER: S-EPMC6034451 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature