Bioactive Extracellular Matrix Scaffold Promotes Adaptive Cardiac Remodeling and Repair.

ABSTRACT: Structural cardiac remodeling after ischemic injury can induce a transition to heart failure from progressive loss of cardiac function. Cellular regenerative therapies are promising but face significant translational hurdles. Tissue extracellular matrix (ECM) holds the necessary environmental cues to stimulate cell-based endogenous myocardial repair pathways and promote adaptive remodeling toward functional recovery. Heart epicardium has emerged as an important anatomic niche for endogenous repair pathways including vasculogenesis and cardiogenesis. We show that acellular ECM scaffolds surgically implanted on the epicardium following myocardial infarction (MI) can attenuate structural cardiac remodeling and improve functional recovery. We assessed the efficacy of this strategy on post-MI f

SUBMITTER: Mewhort HEM 

PROVIDER: S-EPMC6034485 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature