Node-Pore Coded Coincidence Correction: Coulter Counters, Code Design, and Sparse Deconvolution.

ABSTRACT: We present a novel method to perform individual particle (e.g. cells or viruses) coincidence correction through joint channel design and algorithmic methods. Inspired by multiple-user communication theory, we modulate the channel response, with Node-Pore Sensing, to give each particle a binary Barker code signature. When processed with our modified successive interference cancellation method, this signature enables both the separation of coincidence particles and a high sensitivity to small particles. We identify several sources of modeling error and mitigate most effects using a data-driven self-calibration step and robust regression. Additionally, we provide simulation analysis to highlight our robustness, as well as our limitations, to these sources of stochastic system model error. Fin

SUBMITTER: Kellman M 

PROVIDER: S-EPMC6034687 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature