Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation.

ABSTRACT:

Background

Health in early life is crucial for health later in life. Exposure to air pollution during embryonic and early-life development can result in placental epigenetic modification and foetus reprogramming, which can influence disease susceptibility in later life. Objectives: The aim of this paper was to investigate the placental adaptation in the level of global DNA methylation and differential gene expression in the methylation cycle in new-borns exposed to high fine particulate matter in the foetal stage.

Study design

This is a nested case-control study. We enrolled pregnant healthy women attending prenatal care clinics in Tehran, Iran, who were residents of selected polluted and unpolluted regions, before the 14th week of pregnancy. We calculated the regional backg

SUBMITTER: Maghbooli Z 

PROVIDER: S-EPMC6034814 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature