OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses.

ABSTRACT: Optimization of the types and timing of avoidance behaviors depending on the intensity of a noxious stimulus is essential for survival; however, processing in the central nervous system and its developmental basis are largely unknown. Here, we report that Caenorhabditis elegans preferentially selects one of three different types of avoidance behaviors depending on the strength of the noxious stimulus. We screened 210 neuronal transcription factors using a combination of optogenetics and RNA interference methods and identified 19 candidates required for avoidance behaviors. One candidate, gene lin-32 (abnormal cell LINeage 32), which encodes an atonal homolog, is required for the neural fate determination of AIB interneurons and functions by regulating the expression of electrical and chemi

SUBMITTER: Hori S 

PROVIDER: S-EPMC6034901 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature