Genetic diversity and spatial-temporal distribution of Yersinia pestis in Qinghai Plateau, China.

ABSTRACT:

Background

Plague, caused by the bacterium Yersinia pestis, is a highly infectious, zoonotic disease. Hundreds of human plague cases are reported across the world annually. Qinghai Plateau is one of the most severely affected plague regions in China, with more than 240 fatal cases of Y. pestis in the last 60 years. Conventional epidemiologic analysis has effectively guided the prevention and control of local plague transmission; however, molecular genetic analysis is more effective for investigating population diversity and transmission. In this report, we employed different genetic markers to analyze the population structure of Y. pestis in Qinghai Plateau.

Methodology/principal finding

We employed a two-step hierarchical strategy to analyze the phylogeny of 102 Qinghai Pla

SUBMITTER: Xu X 

PROVIDER: S-EPMC6034908 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature