Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care.

ABSTRACT:

Background

Cerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow-up of brain tumors. Ferumoxytol, a long-circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established.

Purpose

To compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time-intensity curves and CBV maps in normal-appearing brain regions.

Study type

Retrospective.

Subjects

Fifty-four patients with various brain disorders.

Field strength/sequence

3T MRI. DSC-MRI was performed with 0.1 mmol/kg gadoteridol and 1 day later with ferumoxytol in doses of 1 or 2 mg/kg.

Assessment

Signal changes during fir

SUBMITTER: Varallyay CG 

PROVIDER: S-EPMC6034979 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature