Bone healing response in cyclically loaded implants: Comparing zero, one, and two loading sessions per day.

ABSTRACT: When bone implants are loaded, they are inevitably subjected to displacement relative to bone. Such micromotion generates stress/strain states at the interface that can cause beneficial or detrimental sequels. The objective of this study is to better understand the mechanobiology of bone healing at the tissue-implant interface during repeated loading. Machined screw shaped Ti implants were placed in rat tibiae in a hole slightly bigger than the implant diameter. Implants were held stable by a specially-designed bone plate that permits controlled loading. Three loading regimens were applied, (a) zero loading, (b) one daily loading session of 60 cycles with an axial force of 1.5 N/cycle for 7 days, and (c) two such daily sessions with the same axial force also for 7 days. Finite element anal

SUBMITTER: de Barros E Lima Bueno R 

PROVIDER: S-EPMC6035061 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature