Circadian Misalignment and Hepatocellular Carcinoma Incidence in the United States.

ABSTRACT: Background: Circadian misalignment may increase the risk of developing hepatocellular carcinoma (HCC). The aim of this study was to examine the association between distance from time zone meridian, a proxy for circadian misalignment, and HCC risk in the United States adjusting for known HCC risk factors.Methods: Surveillance, Epidemiology, and End Results (SEER) provided information on 56,347 HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries in the United States. Distance from time zone meridian was estimated using the location of each SEER county's Center of Population in a geographic information system. Poisson regression with robust variance estimation was used to calculate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) f

SUBMITTER: VoPham T 

PROVIDER: S-EPMC6035064 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature