Cardiovascular Risk Factors Accelerate Kidney Function Decline in Post-Myocardial Infarction Patients: The Alpha Omega Cohort Study.

ABSTRACT:

Introduction

Impaired kidney function is a robust risk factor for cardiovascular mortality. Age-related annual kidney function decline of 1.0 ml/min per 1.73 m² after age 40 years is doubled in post-myocardial infarction (MI) patients.

Methods

We investigated the impact of the number of cardiovascular risk factors (including unhealthy lifestyle) on annual kidney function decline, in 2426 post-MI patients (60-80 years) of the prospective Alpha Omega Cohort study. Glomerular filtration rate was estimated by serum cystatin C (eGFR_cysC) and combined creatinine-cystatin C (eGFR_cr-cysC), using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations from 2012. Data were analyzed by multivariable linear and logistic regression.

R

SUBMITTER: Esmeijer K 

PROVIDER: S-EPMC6035162 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature