Diversity among bla_KPC-containing plasmids in Escherichia coli and other bacterial species isolated from the same patients.

ABSTRACT: Carbapenem resistant Enterobacteriaceae are a significant public health concern, and genes encoding the Klebsiella pneumoniae carbapenemase (KPC) have contributed to the global spread of carbapenem resistance. In the current study, we used whole-genome sequencing to investigate the diversity of bla_KPC-containing plasmids and antimicrobial resistance mechanisms among 26 bla_KPC-containing Escherichia coli, and 13 bla_KPC-containing Enterobacter asburiae, Enterobacter hormaechei, K. pneumoniae, Klebsiella variicola, Klebsiella michiganensis, and Serratia marcescens strains, which were isolated from the same patients as the bla_KPC-containing E. coli. A bla_KPC-containing IncN and/or IncFII_K plasmid was identified in 77% (30/39) of

SUBMITTER: Hazen TH 

PROVIDER: S-EPMC6035167 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature