Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns.

ABSTRACT:

Background

In the early stage of severe burn, patients often exhibit a high level of inflammatory mediators in blood and are likely to develop sepsis. High-volume haemofiltration (HVHF) can eliminate these inflammatory mediators. We hypothesised that early application of HVHF may be beneficial in reducing sepsis and improving the prognosis of patients with severe burns.

Methods

Adults patients with burns ≥ 50% total burn surface area (TBSA) and in whom the sum of deep partial and full-thickness burn areas was ≥ 30% were enrolled in this randomised prospective study, and they were divided into control (41 cases) and HVHF (41 cases) groups. Patients in the control group received standard management for major burns, whereas the HVHF group additionally received HVHF treatment (6

SUBMITTER: You B 

PROVIDER: S-EPMC6035411 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature