Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.

ABSTRACT:

Background

Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. We hypothesized that maternal gut microbiota during pregnancy and breastfeeding is a critical determinant of infant immunity. To test this, pregnant BALB/c dams were fed vancomycin for 5 days prior to delivery (gestation; Mg), 14 days postpartum during nursing (Mn), or during gestation and nursing (Mgn), or no vancomycin (Mc). We analyzed adaptive immunity and gut microbiota in dams and pups at various times after delivery.

Results

In addition to direct alterations to maternal gut microbial composition, pup gut microbiota displayed lowe

SUBMITTER: Nyangahu DD 

PROVIDER: S-EPMC6035804 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature