EMI1 switches from being a substrate to an inhibitor of APC/C^CDH1 to start the cell cycle.

ABSTRACT: Mammalian cells integrate mitogen and stress signalling before the end of G1 phase to determine whether or not they enter the cell cycle^1-4. Before cells can replicate their DNA in S phase, they have to activate cyclin-dependent kinases (CDKs), induce an E2F transcription program and inactivate the anaphase-promoting complex (APC/C^CDH1, also known as the cyclosome), which is an E3 ubiquitin ligase that contains the co-activator CDH1 (also known as FZR, encoded by FZR1). It was recently shown that stress can return cells to quiescence after CDK2 activation and E2F induction but not after inactivation of APC/C^CDH1, which suggests that APC/C^CDH1 inactivation is the point of no return for cell-cycle entry ³ . Rapid inactivation of APC/C

SUBMITTER: Cappell SD 

PROVIDER: S-EPMC6035873 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature