Identification of a novel gene regulating amygdala-mediated fear extinction.

ABSTRACT: Recent years have seen advances in our understanding of the neural circuits associated with trauma-related disorders, and the development of relevant assays for these behaviors in rodents. Although inherited factors are known to influence individual differences in risk for these disorders, it has been difficult to identify specific genes that moderate circuit functions to affect trauma-related behaviors. Here, we exploited robust inbred mouse strain differences in Pavlovian fear extinction to uncover quantitative trait loci (QTL) associated with this trait. We found these strain differences to be resistant to developmental cross-fostering and associated with anatomical variation in basolateral amygdala (BLA) perineuronal nets, which are developmentally implicated in extinction. Next, by pr

SUBMITTER: Gunduz-Cinar O 

PROVIDER: S-EPMC6035889 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature