Noninvasive Relative Quantification of [¹¹C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt.

ABSTRACT: Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [¹¹C]ABP688, the methods for reproducible quantification of [¹¹C]ABP688 PET imaging in mice have not been thoroughly investigated yet. Thus, this study aimed to assess and validate cerebellum as reference region for simplified reference tissue model (SRTM), investigate the feasibility of a noninvasive cardiac image-derived input function (IDIF) for relative quantification, to validate the use of a PET template instead of an MRI template for spatial normalization, and to determine the reproducibility and within-subject variability of [¹¹C]ABP688 PET imaging in mice. Blocking wit

SUBMITTER: Verhaeghe J 

PROVIDER: S-EPMC6036254 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature