Is high serum programmed death ligand 1 level a risk factor for poor survival in patients with gastric cancer?

ABSTRACT:

Background and aim

Although the clinicopathological significance of the expression of programmed death ligand 1(PD-L1) in various cancer tissues has been reported, serum PD-L1 level has not been evaluated in patients with surgically treated gastric cancer. Therefore, we evaluated the clinicopathological characteristics and prognostic significance of preoperative serum PD-L1 levels in patients with gastric cancer.

Patients and methods

Serum samples were obtained before surgery from 152 patients with gastric cancer, including 75 patients with stage I, 31 with stage II, 23 with stage III, and 23 with stage IV gastric cancer. The samples were analyzed using enzyme-linked immunosorbent assay to detect soluble PD-L1. Using the median serum PD-L1 level of 50 pg/mL, patients were di

SUBMITTER: Ito M 

PROVIDER: S-EPMC6036390 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature