Reincarnation of Bacteriocins From the Lactobacillus Pangenomic Graveyard.

ABSTRACT: Bacteria commonly produce narrow spectrum bacteriocins as a means of inhibiting closely related species competing for similar resources in an environment. The increasing availability of genomic data means that it is becoming easier to identify bacteriocins encoded within genomes. Often, however, the presence of bacteriocin genes in a strain does not always translate into biological antimicrobial activity. For example, when analysing the Lactobacillus pangenome we identified strains encoding ten pediocin-like bacteriocin structural genes which failed to display inhibitory activity. Nine of these bacteriocins were novel whilst one was identified as the previously characterized bacteriocin "penocin A." The composition of these bacteriocin operons varied between strains, often with key

SUBMITTER: Collins FWJ 

PROVIDER: S-EPMC6036575 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature