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Visible light-mediated difluoroalkylation of electron-deficient alkenes.

ABSTRACT: A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride.

SUBMITTER: Supranovich VI

PROVIDER: S-EPMC6036985 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Visible light-mediated difluoroalkylation of electron-deficient alkenes.

Supranovich Vyacheslav I VI Levin Vitalij V VV Struchkova Marina I MI Hu Jinbo J Dilman Alexander D AD

Beilstein journal of organic chemistry 20180702

A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride. ...[more]

PMID: 30013689

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