Ontology highlight
ABSTRACT:
SUBMITTER: Neyt NC
PROVIDER: S-EPMC6036987 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Neyt Nicole C NC Riley Darren L DL
Beilstein journal of organic chemistry 20180622
We recently reported a novel hybrid batch-flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction of aldehydes. The method developed affords yields which are comparable to those under batch conditions, has a reduced reaction time and improved space-time productivity. Furthermore, the approach allows the selective reduction of aldeh ...[more]