Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins.

ABSTRACT: Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for the patient. In order to remove the tumor tissue completely with minimal collateral damage to healthy tissue, there is a need for diagnostic tools that will differentiate between the tumor and its normal surroundings. Methods: We designed, synthesized and characterized three novel polymeric Turn-ON probes that will be activated at the tumor site by cysteine cathepsins that are highly expressed in multiple tumor types. Utilizing orthotopic breast canc

SUBMITTER: Blau R 

PROVIDER: S-EPMC6037036 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature