The Effect of Hybridization on Dosage Compensation in Member Species of the Anopheles gambiae Species Complex.

ABSTRACT: Dosage compensation has evolved in concert with Y-chromosome degeneration in many taxa that exhibit heterogametic sex chromosomes. Dosage compensation overcomes the biological challenge of a "half dose" of X chromosome gene transcripts in the heterogametic sex. The need to equalize gene expression of a hemizygous X with that of autosomes arises from the fact that the X chromosomes retain hundreds of functional genes that are actively transcribed in both sexes and interact with genes expressed on the autosomes. Sex determination and heterogametic sex chromosomes have evolved multiple times in Diptera, and in each case the genetic control of dosage compensation is tightly linked to sex determination. In the Anopheles gambiae species complex (Culicidae), maleness is conferred by the Y-chromos

SUBMITTER: Deitz KC 

PROVIDER: S-EPMC6037052 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature