Epidemiology and molecular characterization of multidrug-resistant Escherichia coli isolates harboring bla_CTX-M group 1 extended-spectrum β-lactamases causing bacteremia and urinary tract infection in Manhica, Mozambique.

ABSTRACT:

Background

The emergence and spread of extended-spectrum β-lactamases (ESBLs), especially CTX-M, is an important public health problem with serious implications for low-income countries where second-line treatment is often unavailable. Knowledge of the local prevalence of ESBL is critical to define appropriate empirical therapeutic strategies for multidrug-resistant (MDR) organisms. This study aimed to assess and characterize the presence of ESBL and especially CTX-M-producing Escherichia coli MDR isolates from patients with urinary tract infections (UTIs) and bacteremia in a rural hospital in Mozambique.

Materials and methods

One hundred and fifty-one E. coli isolates from bacteremia and UTI in children were screened for CTX-M, TEM, SHV and OXA β-lactamases by

SUBMITTER: Guiral E 

PROVIDER: S-EPMC6037150 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature