The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3.

ABSTRACT: It has increasingly become clear over the last two decades that proteins can contain both globular domains and intrinsically unfolded regions that can both contribute to function. Although equally interesting, the disordered regions are difficult to study, because they usually do not crystallize unless bound to partners and are not easily amenable to cryo-electron microscopy studies. NMR spectroscopy remains the best technique to capture the structural features of intrinsically mixed folded proteins and describe their dynamics. These studies rely on the successful assignment of the spectrum, a task not easy per se given the limited spread of the resonances of the disordered residues. Here, we describe the structural properties of ataxin-3, the protein responsible for the neurodegenerative

SUBMITTER: Sicorello A 

PROVIDER: S-EPMC6037153 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature