Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies.

ABSTRACT:

Importance

Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, or are interrelated.

Objective

To examine whether the accelerated cognitive decline observed after delirium is independent of the pathologic processes of classic dementia.

Design, setting, and participants

Harmonized data from 987 individual brain donors from 3 observational cohort studies with population-based sampling (Vantaa 85+, Cambridge City Over-75s Cohort, Cognitive Function and Ageing Study) performed from January 1, 1985, through December 31, 2011, with a median follow-up of 5.2 years until death, were used in this study. Neuropathologic as

SUBMITTER: Davis DH 

PROVIDER: S-EPMC6037291 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature