Vertex sliding drives intercalation by radial coupling of adhesion and actomyosin networks during Drosophila germband extension.

ABSTRACT: Oriented cell intercalation is an essential developmental process that shapes tissue morphologies through the directional insertion of cells between their neighbors. Previous research has focused on properties of cell-cell interfaces, while the function of tricellular vertices has remained unaddressed. Here, we identify a highly novel mechanism in which vertices demonstrate independent sliding behaviors along cell peripheries to produce the topological deformations responsible for intercalation. Through systematic analysis, we find that the motion of vertices connected by contracting interfaces is not physically coupled, but instead possess strong radial coupling. E-cadherin and Myosin II exist in previously unstudied populations at cell vertices and undergo oscillatory cycles of accumulat

SUBMITTER: Vanderleest TE 

PROVIDER: S-EPMC6037471 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature