Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.

ABSTRACT:

Objectives

Children undergoing cardiopulmonary bypass develop clinically impactful capillary leak of unclear etiology. A widely held hypothesis that exposure of circulating cells to the cardiopulmonary bypass circuit induces the release of inflammatory mediators that act to disrupt intercellular junctions of capillary endothelial cells inducing paracellular capillary leak either directly or through new gene expression.

Design

Cohort study.

Setting

Tertiary pediatric hospital.

Patients

Twenty children undergoing surgery with cardiopulmonary bypass for congenital heart disease. Serum was collected before cardiopulmonary bypass, 2 hours after cardiopulmonary bypass, and 18 hours after cardiopulmonary bypass.

Interventions

None.

Measurements and main resu

SUBMITTER: Pierce RW 

PROVIDER: S-EPMC6037548 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature