Effectiveness and safety of different amifostine regimens: Preliminary results of a phase II multicenter randomized controlled trial.

ABSTRACT:

Objective

The radioprotective effects of amifostine remain uncertain in patients with nasopharyngeal carcinoma (NPC), and adverse effects and cost limit generalization of its classical everyday regimen. This phase II multicenter randomized controlled trial aimed to explore whether amifostine could ameliorate the toxicities of NPC patients in the era of intensity-modulated radiotherapy (IMRT), and to compare different regimens of amifostine on effectiveness and safety.

Methods

Patients with stage I-IVB NPC were involved prospectively from January 1st, 2013. All patients received radical treatment based on IMRT. After a randomization stratified by their stage, these patients were allocated into 3 groups: the group treated without amifostine, the group treated with the everyday

SUBMITTER: Chang H 

PROVIDER: S-EPMC6037586 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature