MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer.

ABSTRACT:

Objective

Menage a trois 1 (MAT1) is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase, which modulates cell cycle, transcription and DNA repair. Its dysregulation is responsible for diseases including cancers. To further explore the role of MAT1 in breast cancer, we investigated the pathways in which MAT1 might be involved, the association between MAT1 and molecular subtypes, and the role of MAT1 in clinical outcomes of breast cancer patients.

Methods

We conducted immunohistochemistry staining on tissue microarray and immunofluorescence staining on sections of MAT1 stable breast cancer cells. Also, we performed Kyoto Encyclopedia of Genes and Genomes pathway analysis, correlation analysis and prognosis

SUBMITTER: Xu H 

PROVIDER: S-EPMC6037588 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature