Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects.

ABSTRACT:

Purpose

The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels in cerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide polymorphism of SNCA on DAT availability in healthy subjects.

Materials and methods

The study population comprised healthy controls who underwent ¹²³I-FP-CIT single-photon emission computed tomography screening. Five SNCA probes were used to target the boundaries of exon 3 and exon 4 (SNCA-E3E4), transcripts with a long 3'UTR region (SNCA-3UTR-1, SNCA-3UTR-2), transcripts that skip exon 5 (SNCA-E4E6), and the rare short transcript isoforms that comprise exons 1-4 (SNCA-007).

Results

In total, 123 healthy subjects (male 75, female 48) were incl

SUBMITTER: Seo Y 

PROVIDER: S-EPMC6037603 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature