A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome.

ABSTRACT:

Background

The acute respiratory distress syndrome (ARDS) is one of the main causes of mortality in adults admitted to intensive care units. Previous studies have demonstrated the existence of genetic variants involved in the susceptibility and outcomes of this syndrome. We aimed to identify novel genes implicated in sepsis-induced ARDS susceptibility.

Methods

We first performed a prioritization of candidate genes by integrating our own genomic data from a transcriptomic study in an animal model of ARDS and from the only published genome-wide association study of ARDS study in humans. Then, we selected single nucleotide polymorphisms (SNPs) from prioritized genes to conduct a case-control discovery association study in patients with sepsis-induced ARDS (n = 225) and populati

SUBMITTER: Hernandez-Pacheco N 

PROVIDER: S-EPMC6037659 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature