Annexins induce curvature on free-edge membranes displaying distinct morphologies.

ABSTRACT: Annexins are a family of proteins characterized by their ability to bind anionic membranes in response to Ca²⁺-activation. They are involved in a multitude of cellular functions including vesiculation and membrane repair. Here, we investigate the effect of nine annexins (ANXA1-ANXA7, ANXA11, ANXA13) on negatively charged double supported membrane patches with free edges. We find that annexin members can be classified according to the membrane morphology they induce and matching a dendrogam of the annexin family based on full amino acid sequences. ANXA1 and ANXA2 induce membrane folding and blebbing initiated from membrane structural defects inside patches while ANXA6 induces membrane folding originating both from defects and from the membrane edges. ANXA4 and ANXA5 induce cooper

SUBMITTER: Boye TL 

PROVIDER: S-EPMC6037701 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature