Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection.

ABSTRACT: Tuberculosis ranks as one of the world's deadliest infectious diseases causing more than a million casualties annually. IL10 inhibits the function of Th1 type cells, and IL10 deficiency has been associated with an improved resistance against Mycobacterium tuberculosis infection in a mouse model. Here, we utilized M. marinum infection in the zebrafish (Danio rerio) as a model for studying Il10 in the host response against mycobacteria. Unchallenged, nonsense il10^e46/e46 mutant zebrafish were fertile and phenotypically normal. Following a chronic mycobacterial infection, il10^e46/e46 mutants showed enhanced survival compared to the controls. This was associated with an increased expression of the Th cell marker cd4-1 and a shift towards a Th1 type immune response, which

SUBMITTER: Harjula SE 

PROVIDER: S-EPMC6037744 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature