Association Between Cholangiocarcinoma and Proton Pump Inhibitors Use: A Nested Case-Control Study.

ABSTRACT: Background: The present study aimed to examine the odds of cholangiocarcinoma (CCA) in patients with proton pump inhibitors (PPIs) use. Methods: A nested case-control study design was employed using data obtained from Taiwan's National Health Insurance Research Database. In total, 2,293 patients with confirmed diagnosis of CCA were identified and served as the CCA group. The CCA patients were propensity score-matched with 2,293 subjects without CCA who served as the control group. The cumulative defined daily dose (DDD) of PPIs was calculated based on the total supply in days and quantity of individual PPIs. Univariable and multivariate logistic regression models were used to determine the odds of CCA, and calculated odds ratios (ORs) and 95% confidence intervals (CI) were us

SUBMITTER: Peng YC 

PROVIDER: S-EPMC6037835 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature