Urocortin-2 Prevents Dysregulation of Ca²⁺ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion.

ABSTRACT: Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca²⁺ concentration ([Ca²⁺]_i) under I/R. Here, we examined whether the addition of Ucn-2 in reperfusion promotes cardioprotection focusing on ([Ca²⁺]_i handling. Methods and Results: Cardiac Wistar rat model of I/R was induced by transient ligation of the left coronary artery and experiments were conducted 1 week after surgery in tissue and adult cardiomyocytes isolated from risk and remote zones. We observed that I/R promoted significant alteration in cardiac contractility as well as an increase in hypertrophy and fibrosis in both zones. The study

SUBMITTER: Dominguez-Rodriguez A 

PROVIDER: S-EPMC6037857 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature