Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function.

ABSTRACT: ATP-sensitive potassium channels found in both the sarcolemma (sarcK_ATP) and mitochondria (mitoK_ATP) of cardiomyocytes are important mediators of cardioprotection during ischemic heart disease. Sulfonylurea receptor isoforms (SUR2), encoded by Abcc9, an ATP-binding cassette family member, form regulatory subunits of the sarcK_ATP channel and are also thought to regulate mitoK_ATP channel activity. A short-form splice variant of SUR2 (SUR2A-55) was previously shown to target mitochondria and display diaxoxide and ATP insensitive K_ATP activity when co-expressed with the inward rectifier channels Kir6.2 and Kir6.1. We hypothesized that mice with cardiac specific overexpression of SUR2A-55 would mediate cardioprotection from ischemia

SUBMITTER: Ramratnam M 

PROVIDER: S-EPMC6037880 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature