Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer.

ABSTRACT:

Background

Due to difficulties in predicting recurrences in colorectal cancer stages II and III, reliable prognostic biomarkers could be a breakthrough for individualized treatment and follow-up.

Objective

To find potential prognostic protein biomarkers in colorectal cancer, using the proximity extension assays.

Methods

A panel of 92 oncology-related proteins was analyzed with proximity extension assays, in plasma from a cohort of 261 colorectal cancer patients with stage II-IV. The survival analyses were corrected for disease stage and age, and the recurrence analyses were corrected for disease stage. The significance threshold was adjusted for multiple comparisons.

Results

The plasma proteins expression levels had a greater prognostic relevance in disease sta

SUBMITTER: Birgisson H 

PROVIDER: S-EPMC6037900 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature