Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.

ABSTRACT: Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring ¹ marked by the production of substantial amounts of itaconate, which has recently been described as an immunoregulatory metabolite ² . Itaconate and its membrane-permeable derivative dimethyl itaconate (DI) selectively inhibit a subset of cytokines ² , including IL-6 and IL-12 but not TNF. The major effects of itaconate on cellular metabolism during macrophage activation have been attributed to the inhibition of succinate dehydrogenase^2,3, yet this inhibition alone is not sufficient to account for the pronounced immunoregulatory effects observed in the case of DI. Furthermore, the regulatory pat

SUBMITTER: Bambouskova M 

PROVIDER: S-EPMC6037913 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature