Test-Retest Data for Radiomics Feature Stability Analysis: Generalizable or Study-Specific?

ABSTRACT: Radiomics is an objective method for extracting quantitative information from medical images. However, in radiomics, standardization, overfitting, and generalization are major challenges to be overcome. Test-retest experiments can be used to select robust radiomic features that have minimal variation. Currently, it is unknown whether they should be identified for each disease (disease specific) or are only imaging device-specific (computed tomography [CT]-specific). Here, we performed a test-retest analysis on CT scans of 40 patients with rectal cancer in a clinical setting. Correlation between radiomic features was assessed using the concordance correlation coefficient (CCC). In total, only 9/542 features have a CCC > 0.85. Furthermore, results were compared with the test-retest results o

SUBMITTER: van Timmeren JE 

PROVIDER: S-EPMC6037932 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature