The prognostic value of metformin for advanced non-small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

The prognostic value of Metformin for concurrent non-small cell lung cancer (NSCLC) has been controversial in previous individual studies and meta-analyses. In order to further investigate the value of this medication, we conducted a systematic review and meta-analysis for patients with advanced or inoperable NSCLC.

Methods

We searched articles from PubMed, Scopus and Web of Science databases; the time interval was from the inception date of the databases to 1 September 2017. Inclusion criteria for eligible studies were: advanced or inoperable NSCLC; Metformin as an experimental group, and non-Metformin usage as a control group; progression-free survival (PFS) or overall survival (OS) as the outcome, with available hazard ratio (HR). Data synthesis was conducted b

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6037960 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature