Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells.
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ABSTRACT:
SUBMITTER: Alivernini S
PROVIDER: S-EPMC6038003 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells.
Alivernini S S Tolusso B B Ferraccioli G G Gremese E E Kurowska-Stolarska M M McInnes I B IB
Clinical and experimental immunology 20180202 1
Acute inflammation is a complex and tightly regulated homeostatic process that includes leucocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair. However, if inflammation is uncontrolled as in chronic diseases such as rheumatoid arthritis (RA), it leads to tissue damage and disability. Synovial tissue inflammation in RA patients is maintained by sustained activation of multiple inflammatory positive-feedb ...[more]
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