Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.

ABSTRACT:

Background

Inflammation, metabolism, and epigenetic modulation are highly interconnected processes that can be altered during tumorigenesis. However, because of the complexity of these interactions, direct cause and effect during tumorigenesis have been difficult to prove. Previously, using a murine model of inflammation-induced colon tumorigenesis, we determined that the promoter of the catalytic subunit of DNA polymerase gamma (Polg) is DNA hypermethylated and silenced in inflammation-induced tumors, but not in non-inflammation-induced (mock) tumors, suggesting that inflammation can induce silencing of Polg through promoting DNA methylation during tumorigenesis. Polg is the only mitochondrial DNA polymerase and mutations in Polg cause mitochondrial dis

SUBMITTER: Maiuri AR 

PROVIDER: S-EPMC6038244 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature