MiR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.

ABSTRACT:

Background

Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade through degradation of the basement membrane and surrounding stroma. Cortactin, a critical component of invadopodia, frequently used as an invadopodia marker, a universally important player in invadopodia function, and is frequently overexpressed in cancer, but the exact mechanism of regulation is not yet fully understood.

Methods

The expression level of CTTN in human non-small cell lung cancer (NSCLC) tissues was detected by qRT-PCR. Cell migration, invasion and invadopodia formation were assessed in vitro by wound-healing, transwell assay and immunofluoresc

SUBMITTER: Li Y 

PROVIDER: S-EPMC6038252 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature