Ontology highlight
ABSTRACT:
SUBMITTER: Timofeev VI
PROVIDER: S-EPMC6038453 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20180626 Pt 7
Escherichia coli purine nucleoside phosphorylase (PNP), which catalyzes the reversible phosphorolysis of purine ribonucleosides, belongs to the family I hexameric PNPs. Owing to their key role in the purine salvage pathway, PNPs are attractive targets for drug design against some pathogens. Acyclovir (ACV) is an acyclic derivative of the PNP substrate guanosine and is used as an antiviral drug for the treatment of some human viral infections. The crystalline complex of E. coli PNP with acyclovir ...[more]