HiPiler: Visual Exploration of Large Genome Interaction Matrices with Interactive Small Multiples.

ABSTRACT: This paper presents an interactive visualization interface-HiPiler-for the exploration and visualization of regions-of-interest in large genome interaction matrices. Genome interaction matrices approximate the physical distance of pairs of regions on the genome to each other and can contain up to 3 million rows and columns with many sparse regions. Regions of interest (ROIs) can be defined, e.g., by sets of adjacent rows and columns, or by specific visual patterns in the matrix. However, traditional matrix aggregation or pan-and-zoom interfaces fail in supporting search, inspection, and comparison of ROIs in such large matrices. In HiPiler, ROIs are first-class objects, represented as thumbnail-like "snippets". Snippets can be interactively explored and grouped or laid out automatically in

SUBMITTER: Lekschas F 

PROVIDER: S-EPMC6038708 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature