Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents.

ABSTRACT: The Candida genus comprises opportunistic fungi that can become pathogenic when the immune system of the host fails. Candida albicans is the most important and prevalent species. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat candidiasis. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented among several Candida species. The advent of original and re-emergence of classical fungal diseases have occurred as a consequence of the development of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The design of original drugs from traditi

SUBMITTER: de Oliveira Santos GC 

PROVIDER: S-EPMC6038711 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature